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doi:10.2147/DDDT.S328228

In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions

It was noted that lapatinib at the dose of 100 mg/kg exhibited more evident protection against seizure phenotype than that by the dose of 50 and 100 mg/kg lapatinib had no significant effect on weight gain, indicating a good tolerance of lapatinib (Figure 1F)